BUY CHEAP HYTRINProduct info: Blood Pressure - Hytrin
Hytrin: Hytrin (Terazosin) is prescribed to reduce high blood pressure. It may be used alone or in combination with other blood pressure lowering drugs, such as HydroDIURIL (a diuretic) or Inderal, a beta blocker.
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Hytrin
Generic Name: terazosin hydrochloride
Dosage Form: capsules
Description
Hytrin (terazosin hydrochloride), an alpha-1-selective adrenoceptor blocking agent, is a quinazoline derivative represented by the following chemical name and structural formula:
(RS)-Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetra-hydro-2-furanyl)carbonyl]-, monohydrochloride, dihydrate.
Terazosin hydrochloride is a white, crystalline substance, freely soluble in water and isotonic saline and has a molecular weight of 459.93. Hytrin capsules (terazosin hydrochloride capsules) for oral ingestion are supplied in four dosage strengths containing terazosin hydrochloride equivalent to 1 mg, 2 mg, 5 mg, or 10 mg of terazosin.
Inactive Ingredients
1 mg capsules: gelatin, glycerin, iron oxide, methylparaben, mineral oil, polyethylene glycol, povidone, propylparaben, titanium dioxide, and vanillin.
2 mg capsules: D&C yellow No. 10, gelatin, glycerin, methylparaben, mineral oil, polyethylene glycol, povidone, propylparaben, titanium dioxide, and vanillin.
5 mg capsules: D&C red No. 28, FD&C red No. 40, gelatin, glycerin, methylparaben, mineral oil, polyethylene glycol, povidone, propylparaben, titanium dioxide, and vanillin.
10 mg capsules: FD&C blue No. 1, gelatin, glycerin, methylparaben, mineral oil, polyethylene glycol, povidone, propylparaben, titanium dioxide, and vanillin.
Hytrin - Clinical Pharmacology
Pharmacodynamics
A. Benign Prostatic Hyperplasia (BPH)
The symptoms associated with BPH are related to bladder outlet obstruction, which is comprised of two underlying components: a static component and a dynamic component. The static component is a consequence of an increase in prostate size. Over time, the prostate will continue to enlarge. However, clinical studies have demonstrated that the size of the prostate does not correlate with the severity of BPH symptoms or the degree of urinary obstruction. The dynamic component is a function of an increase in smooth muscle tone in the prostate and bladder neck, leading to constriction of the bladder outlet. Smooth muscle tone is mediated by sympathetic nervous stimulation of alpha-l adrenoceptors, which are abundant in the prostate, prostatic capsule and bladder neck. The reduction in symptoms and improvement in urine flow rates following administration of terazosin is related to relaxation of smooth muscle produced by blockade of alpha-l adrenoceptors in the bladder neck and prostate. Because there are relatively few alpha-l adrenoceptors in the bladder body, terazosin is able to reduce the bladder outlet obstruction without affecting bladder contractility.
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